Cushing’s Syndrome and Weight Gain

Dr. Christopher McGowan
July 12, 2022

Unexplained weight gain is an unwelcome development for almost anyone; indeed, apart from body builders and certain other types of athletes, few people actually want to gain weight. Yet, to medical professionals, true unexplained weight gain is not the same thing as weight gained because a person is unexpectedly in a calorie surplus. As much as that might surprise us, it is still explainable due to dietary choices (often among other factors). A rare but accurate example of this kind of weight gain can be seen with the condition known as Cushing’s syndrome.  

What is Cushing’s Syndrome?   

Cushing’s syndrome, like any other syndrome, is a set of signs and symptoms that are known to cluster together. In this case, the signs and symptoms of Cushing’s syndrome are related to the overproduction of cortisol, a type of steroid hormone produced by the adrenal gland. Cortisol, also sometimes known as the “stress hormone,” is part of the glucocorticoid class of hormones and helps the body respond to stress, reduce inflammation, regulate blood sugar and metabolism, and maintain blood pressure levels. As valuable as cortisol is, too much in the body can cause a variety of health problems.

There are two types of Cushing’s syndrome (also sometimes known as Cushing syndrome) that are differentiated by the basic cause: endogenous and exogenous. Endogenous Cushing’s syndrome means that the prolonged increase in the hormone cortisol came from some reason inside the body; this type is very rare, affecting only about 70 people out of a million each year. Exogenous Cushing’s syndrome, by contrast, means that the increase in cortisol came from an external source. While it is unclear quite how prevalent exogenous Cushing’s syndrome is, it is by far the most common type.  

Symptoms of Cushing’s Syndrome   

The symptoms that define and identify Cushing’s syndrome are the same regardless of whether it is endogenous or exogenous. Most patients develop at least a few of the associated symptoms, and they do tend to get worse over time. Generally speaking, the type and severity of symptoms depend on the amount of excess cortisol in the body and the duration of this excess. Below are the most common symptoms: 

  • Weight gain: Gradual weight gain is the most common symptom of Cushing’s syndrome, and it is especially apparent in the face, neck, and abdomen. In fact, most people will continue to have thin limbs even as other parts of the body get heavier. 
  • Skin changes: Another common effect of Cushing’s is for the skin to become thinner and more fragile. In addition to being more susceptible to infection, the skin is also more easily bruised. Purple stretch marks known as striae are also likely to develop in areas of the body that have gone through weight gain. 
  • Problems for women: Women are generally three times more likely than men to get Cushing’s syndrome, and that comes with some symptoms that are unique to women. One is having either infrequent or missing menstruation periods. Also, the increase in cortisol can include an increase in androgen, the male hormone responsible for body hair; this can lead to hirsutism, excessive hair growth that is typically associated with male bodies. 
  • Muscle weakness: People who have had high levels of cortisol for a long time may begin to experience gradual weakening in the muscles of the thighs and shoulders. This can make it difficult to stand up out of a sitting position or walk up stairs. 
  • Bone loss: Another possible symptom of long-term Cushing’s is the development of osteoporosis, the loss of bone mass. This can make it much easier to break bones in the legs, ribs, and spinal column. 
  • Prediabetes: Because cortisol is involved in the regulation of blood sugar, an excess amount may result in overall higher blood glucose levels. And just like in those without Cushing’s syndrome, eventually high blood sugar can lead to insulin resistance and prediabetes, the precursor to type 2 diabetes
  • High blood pressure: As noted, cortisol is also involved in the regulation of blood pressure; excess levels thus increase blood pressure (hypertension), which can then put added stress on the cardiovascular system. 
  • Psychological problems: About half of patients with Cushing’s syndrome experience psychological symptoms like depression, anxiety, irritability, and lack of emotional control. Some people also experience regular insomnia. 
  • Infection: Because high cortisol levels can also suppress some immune activity and responsivity, patients are often more susceptible to infections of various kinds. 

What Causes Cushing’s Syndrome? 

The most common cause of Cushing’s syndrome is the long-term use of high-dose glucocorticoid medications. These oral medications (corticosteroids like prednisone) are used to treat inflammatory conditions like asthma and rheumatoid arthritis. It is also possible for Cushing’s to develop as a result of using injectable corticosteroids; injections like these are often used for joint pain and back pain. In both cases, the medication causes a higher than normal amount of cortisol to be present in the body.   

If the cause of Cushing’s syndrome can’t be explained by glucocorticoids, then the next most likely cause is a tumor in the pituitary gland. The pituitary gland is located at the base of the brain and produces adrenocorticotropic hormone (ACTH), a hormone that signals the adrenal glands to make cortisol. When a tumor is present, the pituitary gland makes an excess amount of ACTH; that, in turn, causes the adrenal glands to make too much cortisol. The National Institute of Diabetes and Digestive and Kidney Diseases estimates that 8 of 10 non-medication-related cases are due to a pituitary tumor. 

Another similar type of tumor occurs in the adrenal glands; tumors located in the adrenal glands tend to also cause an increase in cortisol production. There are also some tumors that can lead to Cushing’s in an indirect way. These are known as ectopic ACTH-producing tumors, and they involve the tumor causing an organ to produce ACTH that would not normally produce ACTH. The most common example of this is tumors in the lungs, but it can also happen in the thymus, pancreas, and thyroid. Like in the pituitary gland, these tumors cause an increase in the production of ACTH that subsequently causes an increase in the production of cortisol. Ectopic ACTH-producing tumors can sometimes be cancerous.    

How is Cushing’s Syndrome Diagnosed?        

Cushing’s syndrome is primarily a disorder of the endocrine system, the network of glands that acts as the body’s messenger system. Therefore to diagnose Cushing’s, a patient experiencing some of the symptoms listed above will usually require tests from an endocrinologist. Determining the current cortisol levels is naturally one of the first steps, and this can be done via urine tests and blood tests. In some cases the doctor will utilize a low-dose dexamethasone suppression test; if you have Cushing’s syndrome, the low dose of dexamethasone will be unable to suppress cortisol production as it would in an otherwise healthy person. 

Once a diagnosis has been confirmed, further blood tests are needed to determine the precise cause. Magnetic resonance imaging (MRI) may be used to visualize the pituitary gland, adrenal glands, lungs, and abdomen. If a tumor in the pituitary gland is suspected, the doctor may next use a corticotropin-releasing hormone test; if a tumor is present, the corticotropin-releasing hormone (CRH) will cause an increase in ACTH and cortisol levels. Low levels of ACTH in general may indicate the presence of tumors in the adrenal glands. A further clarifying test is the high-dose dexamethasone suppression test; this helps the doctor determine if a tumor elsewhere may be present by examining the effect of dexamethasone on the suppression of cortisol.  

Treatment Options for Cushing’s Syndrome

Depending on the underlying cause determined by a doctor, the treatment can vary greatly. Many cases of Cushing’s syndrome turn out to be exogenous and specifically due to taking high doses of glucocorticoids like prednisone that were prescribed for another condition (like rheumatoid arthritis). In such cases, simply discontinuing the medication will usually resolve the symptoms. 

If a tumor is detected in the pituitary gland (typically a pituitary adenoma), surgery is the standard procedure. If surgery isn’t able to restore normal cortisol production, the doctor may look to medication; examples include cabergoline and mifepristone. As with other types of tumors, radiation therapy may be used in conjunction with surgery. In rare cases, surgical removal of the adrenal glands may be required; this method then requires lifelong daily hormone replacement therapy.  

True You Weight Loss Solutions

Cushing’s syndrome may involve some unexplained weight gain, but for most people the explanation is much more simple. But even if lifestyle choices were ultimately the cause of your weight gain, the solution usually requires a different approach. At True You Weight Loss, we provide alternative weight loss solutions that can help you lose weight and keep it off permanently. If you’d like to learn more about our services, please contact us today to request a consultation

Dr. Christopher McGowan
Dr. Christopher McGowan

Dr. Christopher McGowan, MD, a leader in endobariatrics, specializes in non-surgical obesity treatments and is triple-board-certified in Internal Medicine, Gastroenterology, and Obesity Medicine. Renowned for pioneering endoscopic sleeve gastroplasty (ESG) with over 2,000 procedures, his global influence and research contributions define him as a top expert.

Get Monthly Updates About Nutrition and Advancements in Weight Loss

You might also be interested in:

Learn more about our non-surgical weight loss solutions with a quick consultation.

0% interest financing available.
Discover which solution is right for you.
Go over pricing & payment options.

Fill out the short form to learn more!

Request a Free Consultation

Subscribe to our newsletter for exclusive insights, success stories, and expert tips on non-surgical weight loss. Join our community and stay informed on the latest advancements in endobariatric procedures.
 True You Weight Loss | All rights reserved